Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) is a clinical research study that will investigate three treatments for type 2 diabetes for kids ages 10 through 17. It is funded by the National Institutes of Health. TODAY began recruiting kids with type 2 diabetes in 2004 and the study will continue through 2009. Participants will be followed for 2 to 5 years. Recruitment is still open according to ClinicalTrials.gov.
The three treatment plans include:
- Metformin (500-1000 mg bid)
- Metformin (500-1000 mg bid) plus rosiglitazone (4 mg bid)
- Metformin plus a lifestyle intervention called the TODAY Lifestyle Program (TLP). This program teaches healthy diet changes, increases physical activity to bring about moderate weight loss.
With all of the recent publicity surrounding rosiglitazone, parents may be concerned about it's inclusion in the study. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has issued a press release stating that:
"After carefully reviewing all safety data, including analyses that specifically examine rosiglitazone’s effects on cardiovascular risk factors and bone density, the TODAY study DSMB found no cause for concern and recommended that the TODAY trial continue without change. The DSMB will continue to monitor closely TODAY safety data as well as other available data related to rosiglitazone."
The TODAY Study is taking place at 13 sites in the United States. To see if your child qualifies for the study, visit this link: Inclusion and Exclusion Criteria for TODAY Study.
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